Background: Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies\r\nhave been performed on the association between alcohol consumption and CKD or renal function, it remains\r\ncontroversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney\r\nfunction. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in\r\nJapanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension,\r\nserum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study\r\nwas to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal\r\nfunction in male Japanese health check-up examinees.\r\nMethods: A total of 394 male subjects aged 29ââ?¬â??76 years were selected from among individuals visiting the\r\nhospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the\r\ncombined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated\r\nglomerular filtration rate (eGFR) (<90 ml/min/1.73 m2) was conducted.\r\nResults: For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of\r\nmildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005).\r\nThe crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092,\r\n95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does\r\nnot appear to affect eGFR.\r\nConclusion: The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR\r\nand the risk of mildly decreased eGFR in male Japanese subjects.
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